AKOS BBS-00000215
2-chlorolepidine
CAS: 634-47-9
Molecular Formula: C10H8ClN
AKOS BBS-00000215 - Names and Identifiers
| Name | 2-chlorolepidine |
| Synonyms | AKOS BB-6898 Chlorolepidine 3-chlorolepidine 2-chlorolepidine 2-CHLOROLEPIDINE AKOS BBS-00000215 OTAVA-BB BB0116110026 2-chloro-4-methyl-quinolin 2-Chloro-4-methylquinoline 2-CHLORO-4-METHYLQUINOLINE |
| CAS | 634-47-9 |
| EINECS | 211-209-3 |
| InChI | InChI=1/C10H8ClN/c1-7-6-10(11)12-9-5-3-2-4-8(7)9/h2-6H,1H3 |
AKOS BBS-00000215 - Physico-chemical Properties
| Molecular Formula | C10H8ClN |
| Molar Mass | 177.63 |
| Density | 1.1810 (rough estimate) |
| Melting Point | 55-58°C(lit.) |
| Boling Point | 296°C(lit.) |
| Flash Point | 296°C |
| Vapor Presure | 0.0026mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Almost white |
| BRN | 118333 |
| pKa | 0.98±0.50(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.6224 (estimate) |
| Physical and Chemical Properties | White needle-like crystals. The melting point of 59 degrees, the boiling point of 296 degrees, can be volatilized with water vapor. |
AKOS BBS-00000215 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36 - Wear suitable protective clothing. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29334900 |
AKOS BBS-00000215 - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| Introduction | 4-methyl-2-chloro-quinoline is an organic intermediate, it can be prepared by reacting 4-methylquinolin-2 (1H)-one with phosphorus oxychloride. It has been reported that it can be used to prepare graphite electrode modified by CrO-FeO-PbO and quinoline and a modified vermiculite adsorbent for the adsorption and removal of benzene in chemical wastewater. |
| preparation method | Take 5.0g of 4-methylquinolin-2 (1H)-One and 40ml of phosphorus oxychloride. Place phosphorus oxychloride in a three-necked flask with a stirrer, slowly add 4-methylquinolin-2 (1H)-One powder, slowly raise the temperature to reflux, stir the reaction for 20min, and stop the reaction, most of the solvent phosphorus oxychloride was removed by Rotary distillation under reduced pressure. The residue was poured into ice water, adjusted to Neutral with aqueous sodium hydroxide solution, and precipitated, extracted with ether for three times, washed with water for three times, and dried over anhydrous magnesium sulfate, it was left to evaporate and dried naturally, and colorless needle-like crystals of 4-methyl-2-chloro-quinoline were precipitated, and the yield was 94%. |
| Use | for organic synthesis. |
| production method | a mixture of 2-hydroxy-4-methylquinoline and phosphorus oxychloride was heated to 80-85 °c, after the solid matter is completely dissolved, the mixture is poured into ice water, and the mixture is extracted with diethyl ether. After the diethyl ether extract is distilled off, distillation is performed under reduced pressure to collect the fraction at 132-135 ° C. (0.4kPa), that is, 2-chloro-4-methylquinoline. Further purification can be carried out by recrystallization from petroleum ether (boiling point 40-50 ° C.) in 86%-89% yield. |
Last Update：2024-04-09 02:00:10
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CAS: 634-47-9
Tel: 0714-3999186
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Mobile: 86+15671228036
QQ: 2853786052
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